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Protein protection discovered – Worldwide Cancer Research – #livercancer

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RESEARCHERS DISCOVER PROTEIN THAT PROTECTS AGAINST FATTY LIVER, THE MOST COMMON LIVER DISEASE IN WESTERN COUNTRIES.

The study, partly funded by Worldwide Cancer Research, reveals for the first time that the protein CPEB4 can prevent fatty liver disease. The results were published today in Nature Cell Biology.

A team co-led by two Worldwide Cancer Research scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the IDIBAPS Biomedical Research Institute (part of the Hospital Clínic de Barcelona) has revealed the ability of the protein CPEB4 to prevent fatty liver disease. This condition generally leads to chronic inflammation (non-alcoholic steatohepatitis), which can trigger fibrosis, cirrhosis and ultimately liver cancer. This study, on the basic biology of the liver, paves the way to examine new therapeutic strategies to fight and prevent fatty liver disease. The results have appeared in Nature Cell Biology in the last 24 hours.

CPEB4 and fatty liver

The scientists depleted the levels of CPEB4 in mouse livers in order to study the role of this protein. They observed that the mice developed fatty liver as they aged. Furthermore, young CPEB4-depleted mice fed a high-fat diet also developed this condition.

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